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Hideo Shindou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages
Daisuke Matsuda et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2008)
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
Jing Yang et al.
CELL (2008)
Identification of the interaction site within acyl-CoA: Cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A
Akash Das et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition
Jahangir Iqbal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss
J. Mark Brown et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Identification of putative active site residues of ACAT enzymes
Akash Das et al.
JOURNAL OF LIPID RESEARCH (2008)
ACAT as a drug target for Alzheimer's disease
Henri J. Huttunen et al.
NEURODEGENERATIVE DISEASES (2008)
Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex
Yasuomi Urano et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Ghrelin octanoylation mediated by an orphan lipid transferase
Jesus A. Gutierrez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Esculeogenin A, a new tomato sapogenol, ameliorates hyperlipidemia and atherosclerosis in ApoE-deficient mice by inhibiting ACAT
Yukio Fujiwara et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
Functionality of the seventh and eighth transmembrane domains of acyl-coenzyme A: Cholesterol acyltransferase 1
Zhan-Yun Guo et al.
BIOCHEMISTRY (2007)
A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels
Mami Ikenoya et al.
ATHEROSCLEROSIS (2007)
Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes
Taichi Ohshiro et al.
JOURNAL OF ANTIBIOTICS (2007)
Liver-specific inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice
Thomas A. Bell et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)
A critical role for the histidine residues in the catalytic function of acyl-CoA:cholesterol acyltransferase catalysis:: Evidence for catalytic difference between ACAT1 and ACAT2
Sojin An et al.
FEBS LETTERS (2006)
Effect of ACAT inhibition on the progression of coronary atherosclerosis
SE Nissen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Human acyl-CoA:cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma
BL Song et al.
BIOCHEMICAL JOURNAL (2006)
Human Acyl-CoA:Cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis
C Chang et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2006)
Protein sensors for membrane sterols
JL Goldstein et al.
CELL (2006)
Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells:: ApoE structure as a potential therapeutic target
SM Ye et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The active site His-460 of human acyl-coenzyme A:cholesterol acyltransferase 1 resides in a hitherto undisclosed transmembrane domain
ZY Guo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols:: in vitro and intact cell studies
J Liu et al.
BIOCHEMICAL JOURNAL (2005)
Human urotensin II accelerates foam cell formation in human monocyte-derived macrophages
T Watanabe et al.
HYPERTENSION (2005)
Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) inhibitors as hypolipidemic and antiatherosclerosis drugs
C Leon et al.
PHARMACEUTICAL RESEARCH (2005)
ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia
LL Rudel et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1
YR Su et al.
CIRCULATION (2005)
The disulfide linkage and the free sulfhydryl accessibility of acyl-coenzyme A:Cholesterol acyltransferase 1 as studied by using mPEG5000-maleimide
ZY Guo et al.
BIOCHEMISTRY (2005)
Cytokine regulation of macrophage functions in atherogenesis
A Daugherty et al.
JOURNAL OF LIPID RESEARCH (2005)
Quantitative analysis of the expression of ACAT1 genes in human tissues by real-time PCR2
JL Smith et al.
JOURNAL OF LIPID RESEARCH (2004)
Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness
AT Lada et al.
JOURNAL OF LIPID RESEARCH (2004)
Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone
L Yang et al.
CELL RESEARCH (2004)
Cholesterol, statins and dementia
B Wolozin
CURRENT OPINION IN LIPIDOLOGY (2004)
Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme A:: Cholesterol acyltransferase 2 have opposite atherosclerotic potential
RG Lee et al.
CIRCULATION RESEARCH (2004)
ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: Impact on hepatic cholesterol homeostasis
JJ Repa et al.
HEPATOLOGY (2004)
Human acyl-coenzyme A:cholesterol acyltransferase 1 (acat1) sequences located in two different chromosomes (7 and 1) are required to produce a novel ACAT1 isoenzyme with additional sequence at the N terminus
L Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Overexpression of human diacylglycerol acyltransferase 1, Acyl-CoA:cholesterol acyltransferase 1, or Acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells
JJ Liang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease
B Hutter-Paier et al.
NEURON (2004)
ACAT2 is localized to Hepatocytes and is the major cholesterol-esterifying enzyme in human liver
P Parini et al.
CIRCULATION (2004)
Adiponectin down-regulates acyl-coenzyme A:cholesterol acyltransferase-1 in cultured human monocyte-derived macrophages
K Furukawa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Mass-production of human ACAT-1 and ACAT-2 to screen isoform-specific inhibitor: a different substrate specificity and inhibitory regulation
KH Cho et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor
J Sahi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
B Feng et al.
NATURE CELL BIOLOGY (2003)
Cholesterol:: from heart attacks to Alzheimer's disease
RL Raffaï et al.
JOURNAL OF LIPID RESEARCH (2003)
Human acyl-coenzyme A:cholesterol acyltransferase expressed in Chinese hamster ovary cells:: Membrane topology and active site location
S Lin et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Cholesterol is superior to 7-ketocholesterol or 7α-hydroxycholesterol as an allosteric activator for acyl-coenzyme A:cholesterol acyltransferase 1
Y Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice
EL Willner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Acyl-coenzyme A : cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: In vivo and in vitro studies
N Sakashita et al.
LABORATORY INVESTIGATION (2003)
Stabilization of atherosclerotic plaques: New mechanisms and clinical targets
P Libby et al.
NATURE MEDICINE (2002)
Role of the N-terminal hydrophilic domain of acyl-coenzyme A:cholesterol acyltransferase I on the enzyme's quaternary structure and catalytic efficiency
CJ Yu et al.
BIOCHEMISTRY (2002)
Mutant acyl-coenzyme A:cholesterol acyltransferase 1 devoid of cysteine residues remains catalytically active
XH Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Anti-atherogenic effects of the acyl-CoA : cholesterol acyltransferase inhibitor, avasimibe (CI-1011), in cultured primary human macrophages
A Rodriguez et al.
ATHEROSCLEROSIS (2002)
The enzymes of neutral lipid synthesis
KK Buhman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Influence of membrane partitioning on inhibitors of membrane-bound enzymes
R Homan et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2001)
Acyl-coenzyme A:cholesterol acyltransferase modulates the generation of the amyloid β-peptide
L Puglielli et al.
NATURE CELL BIOLOGY (2001)
The in-vitro influence of serum amyloid A isoforms on enzymes that regulate the balance between esterified and un-esterified cholesterol
S Ely et al.
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2001)
Efficacy and short-term safety of a new ACAT inhibitor, avasimibe, on lipids, lipoproteins, and apolipoproteins, in patients with combined hyperlipidemia
W Insull et al.
ATHEROSCLEROSIS (2001)
Synergistic transcriptional activation of human acyl-coenzyme A:: Cholesterol acyltransterase-1 gene by interferon-γ and all-trans-retinoic acid THP-1 cells
JB Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and-2
TY Chang et al.
CURRENT OPINION IN LIPIDOLOGY (2001)
Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages
S Fazio et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Mammalian acyl-CoA: cholesterol acyltransferases
KF Buhman et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2000)
Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice
KK Buhman et al.
NATURE MEDICINE (2000)
ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane
CW Joyce et al.
MOLECULAR BIOLOGY OF THE CELL (2000)
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
M Accad et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
The ACAT inhibitor avasimibe reduces macrophages and matrix metalloproteinase expression in atherosclerotic lesions of hypercholesterolemic rabbits
TMA Bocan et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2000)
Localization of human acyl-coenzyme A : cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues
N Sakashita et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
A superfamily of membrane-bound O-acyltransferases with implications for Wnt signaling
K Hofmann
TRENDS IN BIOCHEMICAL SCIENCES (2000)
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