期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 294, 期 6, 页码 E1046-E1050出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.00056.2008
关键词
muscle sympathetic nerve activity; arterial blood pressure; otolith stimulation; head-down rotation; estrogen
资金
- NHLBI NIH HHS [HL 088689] Funding Source: Medline
- NIDCD NIH HHS [R01 DC006459, DC 006459] Funding Source: Medline
Evidence suggests that both the arterial baroreflex and vestibulosympathetic reflex contribute to blood pressure regulation, and both autonomic reflexes integrate centrally in the medulla cardiovascular center. A previous report indicated increased sympathetic baroreflex sensitivity during the midluteal (ML) phase of the menstrual cycle compared with the early follicular (EF) phase. On the basis of this finding, we hypothesize an augmented vestibulosympathetic reflex during the ML phase of the menstrual cycle. Muscle sympathetic nerve activity (MSNA), mean arterial pressure ( MAP), and heart rate responses to head-down rotation (HDR) were measured in 10 healthy females during the EF and ML phases of the menstrual cycle. Plasma estradiol (Delta 72 +/- 13 pg/ml, P < 0.01) and progesterone (Delta 8 +/- 2 ng/ml, P < 0.01) were significantly greater during the ML phase compared with the EF phase. The menstrual cycle did not alter resting MSNA, MAP, and heart rate (EF: 13 +/- 3 bursts/min, 80 +/- 2 mmHg, 65 +/- 2 beats/min vs. ML: 14 +/- 3 bursts/min, 81 +/- 3 mmHg, 64 +/- 3 beats/min). During the EF phase, HDR increased MSNA (Delta 3 +/- 1 bursts/min, P < 0.02) but did not change MAP or heart rate (Delta 0 +/- 1 mmHg and Delta 1 +/- 1 beats/min). During the ML phase, HDR increased both MSNA and MAP (Delta 4 +/- 1 bursts/min and Delta 3 +/- 1 mmHg, P < 0.04) with no change in heart rate (Delta 0 +/- 1 beats/min). MSNA and heart rate responses to HDR were not different between the EF and ML phases, but MAP responses to HDR were augmented during the ML phase (P < 0.03). Our results demonstrate that the menstrual cycle does not influence the vestibulosympathetic reflex but appears to alter MAP responses to HDR during the ML phase.
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