期刊
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
卷 295, 期 6, 页码 E1298-E1306出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpendo.90493.2008
关键词
transient receptor potential; sodium current; calcium current; insulin secretion; insulin secretion coupling
资金
- Direccion General de Asuntos del Personal Academico
- Universidad Nacional Autonoma de Mexico [229407]
- Consejo Nacional de Ciencia y Technologia [60065]
- Thrasher Research Fund
Hiriart M, Aguilar-Bryan L. Channel regulation of glucose sensing in the pancreatic beta-cell. Am J Physiol Endocrinol Metab 295: E1298-E1306, 2008. First published October 21, 2008; doi: 10.1152/ajpendo.90493.2008. - Mammalian beta-cells are acutely and chronically regulated by sensing surrounding glucose levels that determine the rate at which insulin is secreted, to maintain euglycemia. Experimental research in vitro and in vivo has shown that, when these cells are exposed to adverse conditions like long periods of hypoglycemia or hyperglycemia, their capability to sense glucose is decreased. Understanding the normal physiology and identifying the main players along this route becomes paramount. In this review, we have taken on the task of looking at the role that ion channels play in the regulation of this process, delineating the different families, and describing the signaling that parallels the glucose sensing process that results in insulin release.
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