期刊
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
卷 307, 期 11, 页码 C979-C985出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00228.2014
关键词
Gpr41; Gpr43; microbiota; Olfr78; SCFAs
资金
- American Heart Association
- Hopkins Digestive Diseases Basic & Translational Research Core Center
Recent studies have highlighted a myriad of ways in which the activity and composition of the gut microbiota can affect the host organism. A primary way in which the gut microbiota affect host physiology is by the production of metabolites, such as short-chain fatty acids (SCFAs), which are subsequently absorbed into the bloodstream of the host. Although recent studies have begun to unravel the ways in which gut microbial SCFAs affect host physiology, less is understood regarding the underlying cell biological mechanisms. In this review, we will outline the known receptors and transporters for SCFAs, and review what is known about the cell biological effects of microbial SCFAs.
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