期刊
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
卷 306, 期 2, 页码 C80-C88出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpcell.00294.2013
关键词
circulating tumor cells; metastasis; coagulation; fluid biopsy
资金
- Oregon Health & Science University Knight Cancer Institute
- National Cancer Institute Grant [U54 CA-143906]
- Medical Research Foundation Early Clinical Investigator Award
- American Heart Association [13EIA12630000]
The identification, isolation, and characterization of circulating tumor cells (CTCs) promises to enhance our understanding of the evolution of cancer in humans. CTCs provide a window into the hematogenous, or fluid phase, of cancer, underlying the metastatic transition in which a locally contained tumor spreads to other locations in the body through the bloodstream. With the development of sensitive and specific CTC identification and isolation methodologies, the role of CTCs in clinical diagnostics, disease surveillance, and the physical basis of metastasis continues to be established. This review focuses on the quantification of the basic biophysical properties of CTCs and the use of these metrics to understand the hematogenous dissemination of these enigmatic cells.
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