期刊
NATURE REVIEWS IMMUNOLOGY
卷 8, 期 6, 页码 421-434出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2322
关键词
-
类别
资金
- NIAID NIH HHS [AI057653, AI074378, R01 AI074378-01A1, R01 AI057653-04, R01 AI074378-03, R01 AI057653-02S1, R01 AI057653, R01 AI074378, R01 AI074378-02, R01 AI057653-02, AI057653-S1, R01 AI057653-03] Funding Source: Medline
IgA class switching is the process whereby B cells acquire the expression of IgA, the most abundant antibody isotype in mucosal secretions. IgA class switching occurs via both T-cell-dependent and T-cell-independent pathways, and the antibody targets both pathogenic and commensal microorganisms. This Review describes recent advances indicating that innate immune recognition of microbial signatures at the epithelial-cell barrier is central to the selective induction of mucosal IgA class switching. In addition, the mechanisms of IgA class switching at follicular and extrafollicular sites within the mucosal environment are summarized. A better understanding of these mechanisms may help in the development of more effective mucosal vaccines.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据