期刊
NEUROCHEMICAL RESEARCH
卷 33, 期 6, 页码 1085-1089出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-007-9554-z
关键词
APP; APP(SWE); transgenic mouse; fractalkine; IP-10; MIP-1 alpha
Chemokines and their receptors have been strongly implicated in the inflammatory process and pathogenesis of the neurodegenerative disorders, such as Alzheimer's disease (AD). In the present study, we examined the expression of chemokines, fractalkine, interferon-inducible protein-10 (IP-10) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) by immunohistochemistry in the brain of transgenic mice APP(SWE) (Tg2576) at ages of 9, 11, and 17 months, which over-express a mutated form of human amyloid precursor protein (APP). Decreased fractalkine and increased IP-10 expression in cerebral cortex and hippocampus were found at ages of 9 and 17 months in Tg2576 mice when compared with age-matched control mice. On the contrary, MIP-1 alpha expression showed no difference between Tg2576 mice and aged controls and was not influenced by ages. beta-amyloid (A beta) positive plaques were co-located with the intense IP-10 expression. The finding suggests fractalkine and IP-10 may participate in the pathogenesis of AD; and could be new therapeutic strategies for neuroprotection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据