期刊
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
卷 92, 期 6, 页码 523-532出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PHM.0b013e31828cd254
关键词
Parkinson Disease; Intensive Rehabilitation; Neuroplasticity
资金
- S. Maugeri Foundation, IRCCS
In the last decade, a considerable number of articles has shown that exercise is effective in improving motor performance in Parkinson disease. In particular, recent studies have focused on the efficacy of intensive exercise in achieving optimal results in the rehabilitation of patients with Parkinson disease. The effects of intensive exercise in promoting cell proliferation and neuronal differentiation in animal models are reported in a large cohort of studies, and these neuroplastic effects are probably related to increased expression of a variety of neurotrophic factors. The authors outline the relation between intensive exercises and neuroplastic activity on animal models of Parkinson disease and discuss the clinical results of different intensive strategies on motor performance and disease progression in patients with Parkinson disease.
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