期刊
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
卷 89, 期 6, 页码 473-486出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PHM.0b013e3181d89b08
关键词
Amputation; Positron Emission Tomography; Ischemia; Peripheral Vascular Diseases
资金
- VA Rehabilitation Research and Development Awards [A2196PA, A2860R]
- Senior Research Career Scientist Award [B2541SA]
Objective: To establish whether muscle blood flow (MBF) measurements with O-15-water positron emission tomography could reliably identify patients with critical limb ischemia and detect and quantify a distal deficit in skeletal MBF in these cases. Design: O-15-water positron emission tomography scans were performed at rest or during unloaded ankle plantar and dorsiflexion exercise of the diseased leg in 17 subjects with leg ischemia or on a randomly selected leg of 18 age-matched healthy control subjects. TcPO2 was evaluated with Novametrix monitors and perfusion of skin topically heated to 44 degrees C and adjacent nonheated areas with a Moor Instruments laser Doppler imaging scanner. Results: The enhancement of MBF induced by exercise was significantly lower in ischemic than in normal legs, and the sensitivity and specificity of this phenomenon were similar to those of laser Doppler imaging or TcPO2 in identifying ischemia subjects. In addition, the exercise MBF deficit was predominant at the distal-leg levels, indicating the ability of the technique to help determine the correct level of amputation. Conclusions: Skeletal MBF of legs with severe ischemia can be detected accurately with O-15-water positron emission tomography and could add valuable information about viability of skeletal muscle in the residual limb when deciding the level of an amputation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据