期刊
NATURE REVIEWS IMMUNOLOGY
卷 8, 期 6, 页码 411-420出版社
NATURE RESEARCH
DOI: 10.1038/nri2316
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- NCI NIH HHS [T32-CA09140-30] Funding Source: Medline
- NIAID NIH HHS [T32-AI007532-08, AI74878, F32-AI72943, AI61570] Funding Source: Medline
- NIGMS NIH HHS [F31-GM82187] Funding Source: Medline
Mucosal surfaces such as the intestinal tract are continuously exposed to both potential pathogens and beneficial commensal microorganisms. This creates a requirement for a homeostatic balance between tolerance and immunity that represents a unique regulatory challenge to the mucosal immune system. Recent findings suggest that intestinal epithelial cells, although once considered a simple physical barrier, are a crucial cell lineage for maintaining intestinal immune homeostasis. This Review discusses recent findings that identify a cardinal role for epithelial cells in sampling the intestinal microenvironment, discriminating pathogenic and commensal microorganisms and influencing the function of antigen-presenting cells and lymphocytes.
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