期刊
AMERICAN JOURNAL OF PERINATOLOGY
卷 28, 期 10, 页码 741-745出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0031-1280854
关键词
Gestational diabetes; glucose intolerance; progesterone
资金
- Centers for Disease Control and Prevention
We compared the rates of abnormal 1-hour glucose challenge tests (GCT) and gestational diabetes (GDM) between women receiving 17 alpha-hydroxyprogesterone caproate (17-P) and women who did not receive 17-P to determine if the effect varies based on the number of doses received or in a group of high-risk obese women. We performed a secondary analysis of a prospective cohort study where women with a history of a previous preterm delivery in the antecedent pregnancy followed at a high-risk clinic were offered 17-P. GCT was performed after the initiation of 17-P, and doses given prior to testing were recorded. Rates of abnormal GCT and GDM were compared between those receiving 17-P (n = 67) and controls (n = 140). Mean glucose values (112.4 versus 111.3, p = 0.8), rate of abnormal GCT (23.9% versus 20%, adjusted odds ratio 1.45, 95% confidence interval 0.7 to 3.0), and rate of GDM (6% versus 8.6%, adjusted odds ratio 1.21, 95% confidence interval 0.3 to 4.5) were similar between groups. In this prospective study, 17-P administration to women at risk of recurrent preterm delivery did not significantly affect glucose tolerance.
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