期刊
AMERICAN JOURNAL OF PERINATOLOGY
卷 28, 期 10, 页码 793-802出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0031-1284229
关键词
SCRN; neuropathology; stillbirth; central nervous system
资金
- Stillbirth Collaborative Research Network (Brown University, Rhode Island) [U10-HD045953]
- Stillbirth Collaborative Research Network (Emory University, Georgia) [U10-HD045925]
- Stillbirth Collaborative Research Network (University of Texas Medical Branch at Galveston, Texas) [U10-HD045952]
- Stillbirth Collaborative Research Network (University of Texas Health Science Center at San Antonio, Texas) [U10-HD045955]
- Stillbirth Collaborative Research Network (University of Utah Health Sciences Center, Utah) [U10-HD045944]
- Stillbirth Collaborative Research Network (RTI International, North Carolina) [U01-HD45954]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
We describe the neuropathologic procedure utilized in the Stillbirth Collaborative Research Network (SCRN), focusing on the examination of central nervous system (CNS) in stillbirth (SB). The SCRN was organized to perform a case-control study to determine the scope and causes of SB. Pathologists at all the participating centers agreed on and used the same standardized neuropathologic techniques. Standardized sections were taken and detailed data were collected. Fresh brain tissue was saved for investigative purposes. A total of 663 women with SB were enrolled into the case-control study: 620 delivered a single stillborn, 42 delivered twins, and 1 delivered triplets. Of the 560 (84.5%) who consented to postmortem examination, 465 (70.1%) also gave consent to the examination of the CNS. In the 440 stillborn infants in whom CNS examination was possible, 248 (56.4%) of the brains were intact, 72 were fragmented (16.4%), and 120 (27.3%) were liquefied. In summary, this is the largest prospective study dedicated to investigate the causes of SB and collect essential information and biological samples in the United States. A protocol for neuropathologic examination was instituted, and a brain tissue repository was created to provide samples and related data for future investigations.
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