期刊
AMERICAN JOURNAL OF PERINATOLOGY
卷 28, 期 6, 页码 425-430出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0030-1268712
关键词
Glomerular filtration rate; preeclampsia; pregnancy
资金
- Dialysis Clinic Inc.
- Louisiana Board of Regents
- NIH [K12 HD43451-01]
- Canadian Institutes for Health Research
- World Health Organization
- Michael Smith Foundation for Health Research
- Child and Family Research Institute
- Preeclampsia Foundation
- International Federation of Gynecology and Obstetrics
Accurate estimation of the glomerular filtration rate (GFR) in patients with preeclampsia requires the collection of a 24-hour urine and can have important therapeutic and diagnostic implications. This procedure is often difficult or impossible to accomplish in this patient group. In this study, the Cockcroft-Gault, the Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulas were evaluated for their accuracy in determining GFR in the setting of preeclampsia. The estimated GFRs calculated from the above formulas were compared with the creatinine clearance values obtained from a 24-hour urine collections in 543 preeclamptic patients recruited from several large hospitals. Additionally, a set of new equations, preeclampsia GFR (PGFR), based on ethnicity, was created. The Cockcroft-Gault, MDRD, and CKD-EPI formulas were inaccurate in predicting GFR and both were significantly less accurate than PGFR. The latter formula provided an estimated GFR that was much closer to the creatinine clearance. Current GFR estimation equations based on serum creatinine values in nonpregnant patients are not reliable measures of renal function in patients with preeclampsia. The use of a new formula (PGFR) is recommended.
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