期刊
AMERICAN JOURNAL OF PERINATOLOGY
卷 25, 期 3, 页码 175-187出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-2008-1061497
关键词
preterm birth; genomics; proteomics
资金
- NICHD NIH HHS [R01 HD047321-05, R01 HD047321-04, R01 HD047321-02, R01 HD047321-03, R01 HD047321-01, R01 HD047321] Funding Source: Medline
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD047321] Funding Source: NIH RePORTER
Premature birth before 37 weeks of gestation is a significant public health problem. Each year, 4.5 million premature infants are born worldwide. Despite extensive research and a variety of interventions, the rate of preterm birth has steadily increased over the past 20 years and reached a high of 12.8% in 2006. The etiology of most preterm births remains elusive and is likely multifactorial, with many pathophysiological pathways involved, such as excessive stretching, oxidative stress, decidual hemorrhage, and infection. Genomics and proteomics have emerged to provide a better comprehension of the pathophysiological conditions leading to preterm birth, thereby providing a perspective for improving neonatal outcome.
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