期刊
AMERICAN JOURNAL OF PATHOLOGY
卷 181, 期 5, 页码 1504-1512出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajpath.2012.07.008
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资金
- NIH (NIH-NIDDK) [R01-DK73414]
- George Whipple Professorship Endowment
- Taiwan Department of Health Clinical Trial and Research Center of Excellence grant (China Medical University, Taichung, Taiwan) [DOH99-TD-B-111-004]
Upon insult, such as infection or tissue injury, the innate and adaptive immune systems initiate a series of responses to defend the body. Recent studies from immune cell-specific androgen receptor (AR) knockout mice demonstrated that androgen and its receptor (androgen/AR) play significant roles in both immune regulations. In the innate immunity, androgen/AR is required for generation and proper function of neutrophils; androgen/AR also regulates wound healing processes through macrophage recruitment and proinflammatory cytokine production. In adaptive immunity, androgen/AR exerts suppressive effects on development and activation of T and B cells. Removal of such suppression causes thymic enlargement and excessive export of immature B cells. Altogether, androgen/AR plays distinct roles in individual immune cells, and targeting androgen/AR may help in treatment and management of immune-related diseases. (Am J Pathol 2012, 181:1504-1512; http://dx.doi.org/10.1016/j.ajpath.2012.07.008)
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