期刊
AMERICAN JOURNAL OF PATHOLOGY
卷 177, 期 1, 页码 15-20出版社
AMER SOC INVESTIGATIVE PATHOLOGY, INC
DOI: 10.2353/ajpath.2010.090955
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- Network of European Fundings for Neuroscience Research [ERA-Net NEURON-48-038]
Aneuploidy, an abnormal number of copies of a genomic region, might be a significant source for neuronal complexity, intercellular diversity, and evolution. Genotnic instability associated with aneuploidy,, however, can also lead to developmental abnormalities and decreased cellular fitness. Here we show that neurons with a more-than-diploid content of DNA are increased in preclinical stages of Alzheimer's disease (AD) and are selectively affected by cell death during progression of the disease. Present findings show that neuronal hyperploidy in AD is associated with a decreased viability. Hyperploidy of neurons thus represents a direct molecular signature of cells prone to death in AD and indicates that a failure of neuronal differentiation is a critical pathogenetic event in AD. (Am J Pathol 2010, 177:15-20; DOI: 10.2353/ajpath.2010.090955)
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