The preventive effect of mitomycin-C on the external auditory canal fibrosis in an experimentally induced animal model

Objective: The aim of this study was to investigate the preventive effect of mitomycin-C (MMC) on external auditory canal (EAC) fibrosis in an animal model. Study design: This is a randomized, controlled animal study. Subjects and methods: Sixteen guinea pigs were used for this study. After the skin of cartilaginous EAC was injured with an electrocautery, the cottonoid soaked in M MC solution with concentration of 0.4 mg/mL was topically applied for 5 minutes to the injured EAC in an MMC-treated group (n = 8). In addition, saline was applied in the control group (n = 8). At 4 weeks after injury, postsurgical changes of EAC were evaluated by histologic examination. Results: External auditory canal fibrosis was induced by injury with electrocautery. The MMC-treated group showed less degree of fibrosis without differences in epithelialization and inflammatory cell infiltration. Conclusion: This study suggests that MMC can be helpful in preventing EAC fibrosis after injury. (c) 2010 Elsevier Inc. All rights reserved.