期刊
EMERGING INFECTIOUS DISEASES
卷 14, 期 7, 页码 1031-1038出版社
CENTER DISEASE CONTROL
DOI: 10.3201/eid1407.070867
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资金
- NCRR NIH HHS [K12RR02324901-01] Funding Source: Medline
- NIAID NIH HHS [K01AI065808-01, K24AI067794-01, K24 AI067794, K01 AI065808] Funding Source: Medline
- PHS HHS [1U01C1000333-01, UR8/CCU715087-06/1] Funding Source: Medline
Data are limited on the attributable outcomes of Clostridium difficile-associated disease (CDAD), particularly in CDAD-endemic settings. We conducted a retrospective cohort study of nonsurgical inpatients admitted for >= 48 hours in 2003 (N = 18,050). The adjusted hazard ratios for readmission (hazard ratio 2.19, 95% confidence interval [CI] 1.87-2.55) and deaths within 180 days (hazard ratio 1.23, 95% CI 1.03-1.46) were significantly different among CDAD case-patients and noncase patients. In a propensity score matched-pairs analysis that used a nested subset of the cohort (N = 706), attributable length of stay attributable to CDAD was 2.8 days, attributable readmission at 180 days was 19.3%, and attributable death at 180 days was 5.7%. CDAD patients were significantly more likely than controls to be discharged to a long-term-care facility or outside hospital. Even in a nonoutbreak setting, CDAD had a statistically significant negative impact on patient illness and death, and the impact of CDAD persisted beyond hospital discharge.
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