期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 38, 期 6, 页码 1104-1111出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-007-0495-9
关键词
autism; head circumference; infant siblings
资金
- NICHD NIH HHS [P50HD066782, R01HD-55741, R01HD039961, R01 HD039961, R01 HD055741, U19HD34565] Funding Source: Medline
- NIMH NIH HHS [U54MH066399, U54 MH066399] Funding Source: Medline
Siblings of children with autism have an increased risk for autism spectrum disorders (ASD). As children with autism often exhibit an atypical trajectory of head circumference (HC) growth, HC may be an indicator of vulnerability to autism. This study investigated whether infant siblings of children with ASD (n = 77) with an atypical trajectory of HC growth were more likely than those without an atypical HC trajectory to develop autism symptoms. Results showed that infants who had larger HC at 12 months, and whose HC growth rate decelerated more rapidly between 12 and 24 months were more likely to exhibit autism symptoms than infants with more typical HC trajectories. Among infant siblings of children with autism, atypical HC growth might alert pediatricians to provide screening and/or referral for further evaluation.
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