期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 42, 页码 23402-23406出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b07432
关键词
graphene; photosensitizer; exfoliation; phototherapy; drug-delivery system
资金
- Japan Society for the Promotion of Science (JSPS) [25-03339]
- JSPS [P13339]
- [23350062]
- Grants-in-Aid for Scientific Research [13F03339, 26286003] Funding Source: KAKEN
- Austrian Science Fund (FWF) [P13339] Funding Source: Austrian Science Fund (FWF)
We report on the application of pristine graphene as a drug carrier for phototherapy (PT). The loading of a photosensitizer, chlorin e6 (Ce6), was achieved simply by sonication of Ce6 and graphite in an aqueous solution. During the loading process, graphite was gradually exfoliated to graphene to give its composite with Ce6 (G-Ce6). This one-step approach is considered to be superior to the graphene oxide (GO)-based composites, which required pretreatment of graphite by strong oxidation. Additionally, the directly exfoliated graphene ensured a high drug loading capacity, 160 wt %, which is about 10 times larger than that of the functionalized GO. Furthermore, the Ce6 concentration for killing cells by G-Ce6 is 6-75 times less than that of the other Ce6 composites including GO Ce6.
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