期刊
AMERICAN JOURNAL OF OPHTHALMOLOGY
卷 158, 期 4, 页码 745-751出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajo.2014.06.006
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资金
- National Institutes of Health, Bethesda, Maryland [R01-EY022691]
PURPOSE: To determine the effect of anti-vascular endothelial growth factor (VEGF) therapy on choroidal thickness in eyes with diabetic macular edema (DME). DESIGN: A retrospective, cohort analysis of 59 eyes from 59 patients with DME without prior anti-VEGF therapy. METHODS: Choroidal thickness was measured using semiautomated segmentation of enhanced depth imaging optical coherence tomography images at 0.5-mm intervals from 2.5 mm nasal to 2.5 mm temporal to the fovea. Changes in choroidal thickness with and without anti-VEGF treatment over 6 months were compared. Best-corrected visual acuity and central foveal thickness were analyzed to evaluate the association of choroidal thickness with functional and anatomic outcomes. RESULTS: Of the 59 eyes with DME, 26 eyes were observed without treatment, whereas 33 underwent intravitreal anti-VEGF therapy (mean number of injections, 2.73) over 6 months. In untreated eyes, there was no significant change in best-corrected visual acuity (P = .098), central foveal thickness (P = .472), or choroidal thickness at all measurements along the macula (P = .057 at the fovea). In eyes treated with anti-VEGF injections, choroidal thickness decreased significantly at the fovea (246.6 to 224.8 pm; P < .001) and at 0.5 mm nasal (240.9 to 221.9 pm; P = .002) and 0.5 mm temporal (249.3 to 224.8 pm; P = .011) to the fovea. The decrease in subfoveal choroidal thickness after anti-VEGF treatment was not associated with the cumulative number of anti-VEGF injections (R-2 = 0.031; P = .327) or to changes in best-corrected visual acuity (R-2 = 0.017; P = .470) or central fovea! thickness (R-2 = 0.040; P = .263). CONCLUSIONS: Central choroidal thickness decreases after anti-VEGF therapy for DME after 6 months, but may not be associated with functional or anatomic outcomes in eyes with DME. (C) 2014 by Elsevier Inc. All rights reserved.
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