期刊
GLYCOCONJUGATE JOURNAL
卷 25, 期 5, 页码 415-425出版社
SPRINGER
DOI: 10.1007/s10719-007-9095-3
关键词
muramyl dipeptide; paclitaxel; chemical conjugation; synergism; immunotherapy; chemotherapy; cancer
Paclitaxel (Taxol (R)) conjugated to muramyl dipeptide (MDP) is described. Biological testing showed that the conjugation of MDP at 2'-O-paclitaxel (2'-O-MTC-01) not only has antitumor activity, but also have immunoenhancement capacity. Compared with paclitaxel or MDP alone or with a mixture of paclitaxel + MDP, (2'-O-MTC-01 significantly increases the production and expression of TNF-alpha and IL-12 from mouse peritoneal macrophages, which demonstrates a synergism of MDP and paclitaxel in one conjugated molecule.
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