期刊
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
卷 66, 期 -, 页码 S22-S30出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/09637486.2015.1035231
关键词
Lipidomics; mechanism of action; metabolomics; mitochondria; soy
资金
- Barry Callebaut-La Morella Nuts SA
- Biotecnologias Aplicadas SA
- Bodega Matarromera SL
- Miguel Torres SA
- Galletas Gullon SA
- Iberfruta SA
- Laboratorios Ordesa SL
- Newbiotechnic SA
- Soria Natural
- Spanish Ministerio de Economia y Competitividad (Centro para el Desarrollo Tecnologico Industrial)
- FEDER
- Biosearch
Mechanism of action of bioactive compounds may be multiple, especially in the food matrix. Therefore, the interplay between these compounds and hosts' physiology, and the consequences of its continuous intake should be considered. In analogy with pharmacodynamics, the bioactive compounds should have both defined targets and mechanisms of action. However, several essential differences arise when considering the heterogeneous nature of the food matrix, the multiplicity of mechanisms and the variety of responses. In order to ascertain a potential mechanism of activity, one should consider both the intended use of the food, the biomarker that will support this claim and previous evidences, examined from current information sources. Once these have been examined, several experimental strategies should be considered, ranging from the choice of preclinical or experimental model, the use of samples from pilot interventional studies and the application of system's biology derived techniques, such as transcriptomics or metabolomics.
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