期刊
AMERICAN JOURNAL OF OPHTHALMOLOGY
卷 153, 期 5, 页码 883-889出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajo.2011.10.033
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资金
- BURROUGHS-WELLCOME PROGRAM IN Biomedical Sciences, Triangle Park, North Carolina
- Foundation Fighting Blindness in Owings Mills, Maryland
- Eye Surgery Fund in New York, New York
- Bernard Becker-Association of University Professors in Ophthalmology in San Francisco, California
- National Eye Institute, Bethesda, Maryland [R01EY018213, R01EY015520]
- Department of Defense, Fort Detrick, Maryland [TS080017-W81XWH-09-1-0575]
- Doris Duke Clinical Research Fellowship Program in New York, New York
- Charles E. Culpeper Scholarship in New York, New York
- Hirschl Trust in New York, New York
- Crowley Research Fund in New York, New York
- Schneeweiss Stem Cell Fund in New York, New York
- Joel Hoffmann Scholarship in New York, New York
- Jonas Family Fund in New York, New York
- Hartford/American Geriatrics Society in New York, New York
- Research to Prevent Blindness in New York, New York
PURPOSE: To describe and correlate the features of astrocytic hamartomas using multimodal imaging. DESIGN: Prospective, noncomparative, observational case series. METHODS: This was a single-center study of 4 patients (8 eyes) with tuberous sclerosis complex. A complete ophthalmologic examination, fundus photography, fundus autofluorescence (FAF), infrared imaging, and spectral-domain optical coherence tomography (SD-OCT) were performed for each patient. Images from each modality were analyzed and compared. RESULTS: In 2 patients, infrared imaging and SD-OCT detected occult retinal astrocytic hamartomas that were not observed on clinical examination or color fundus photography. FAF demonstrated the greatest contrast between lesions and surrounding retina but failed to identify 1 occult lesion that was detected with infrared imaging and SD-OCT. SD-OCT revealed lesions arising from the retinal nerve fiber layer with overlying vitreous adhesions, hyperreflective dots, and optically empty spaces at all depths of the tumor. Hamartomas were hyporeflective on infrared imaging and hypoautofluorescent on FAF. FAF of some lesions demonstrated hyperautofluorescent spots. CONCLUSIONS: Infrared imaging and SD-OCT aid in the detection of astrocytic hamartomas that are not visible on clinical examination or color fundus photography. SD-OCT enhances visualization of structural details. FAF is a useful adjunctive test to obtain greater contrast between lesions and surrounding retina. The ability to monitor structural changes over time in astrocytic hamartomas using SD-OCT may be beneficial for monitoring the success of systemic chemotherapy in the treatment of various tuberous sclerosis tumors. (Am J Ophthalmol 2012;153:883-889. (C) 2012 by Elsevier Inc. All rights reserved.)
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