Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Highly Myopic Eyes

PURPOSE: To measure macular choroidal thickness (CT) in highly myopic eyes using enhanced depth imaging optical coherence tomography (OCT). DESIGN: Retrospective, observational case series. METHODS: Enhanced depth imaging OCT images were obtained in highly myopic eyes (>= 6 diopters [D]). Images of CT were obtained by positioning a spectral-domain OCT device close enough to the eye to acquire an inverted image. CT was measured from the outer border of the retinal pigment epithelium to the inner scleral border at 1000-mu m intervals of a horizontal section from 3 mm temporal to the fovea to 3 mm nasal to the fovea. Statistical analysis was performed to evaluate CT at each location and to correlate CT with age and refractive error. RESULTS: The mean age of the 31 patients (55 eyes) was 59.7 years (+/- 17.6 years; range, 24 to 90 years), and the mean refractive error was - 11.9 D (+/- 3.7 D). The mean subfoveal CT was 93.2 mu m ( 62.5 mu m) and was correlated negatively with age (P = .006), refractive error (P < .001), and history of choroidal neovascularization (P = .013). Regression analysis suggested that subfoveal CT decreased by 12.7 mu m for each decade of life and by 8.7 mu m for each D of myopia. CONCLUSIONS: The choroid in highly myopic eyes is very thin and undergoes further thinning with increasing age and degree of myopia. Abnormalities of the choroid may play a role in the pathogenesis of myopic degeneration. (Am J Ophthalmol 2009;148:445-450. (C) 2009 by Elsevier Inc. All rights reserved.)