期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 207, 期 3, 页码 157-163出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2012.02.009
关键词
antidepressant; depression; malformation; persistent pulmonary hypertension of the newborn infant (PPHN); pregnancy; risk
Antidepressants are used commonly in pregnancy. Physicians who provide health care for pregnant women with depression must balance maternal well-being with potential fetal risks of these medications. Over the last decade, scores of original and review articles have discussed whether selective serotonin reuptake inhibitors-selective serotonin norepinephrine reuptake inhibitors possess risks to the fetus; however, very little has been done to integrate these potential risks, if they exist, into an overall context of a benefit: risk ratio. This review aims at presenting an updated analysis of fetal and maternal exposure to selective serotonin or norepinephrine reuptake inhibitors to allow an evidence-based benefit: risk ratio. When a psychiatric condition necessitates pharmacotherapy, the benefits of such therapy far outweigh the potential minimal risks of cardiac malformations, primary pulmonary hypertension of the newborn infant, or poor neonatal adaptation syndrome.
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