期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 204, 期 6, 页码 S141-S148出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2011.02.042
关键词
infants; influenza hospitalization; influenza vaccine; maternal vaccination; vaccine effectiveness
资金
- Centers for Disease Control and Prevention [U01/IP000017, U01/IP000022, U01/IP000147]
- National Institute of Allergy and Infectious Diseases [K23 AI065805]
- Wachovia Research Fund
- Medimmune for respiratory syncytial virus studies
- Medimmune
- Wyeth
- Novartis
- Sanofi-Pasteur
- CSL
- Centers for Disease Control and Prevention
- Association of Maternal and Child Health Programs
We sought to determine whether maternal vaccination during pregnancy was associated with a reduced risk of laboratory-confirmed influenza hospitalizations in infants <6 months old. Active population-based, laboratory-confirmed influenza surveillance was conducted in children hospitalized with fever and/or respiratory symptoms in 3 US counties from November through April during the 2002 through 2009 influenza seasons. The exposure, influenza vaccination during pregnancy, and the outcome, positive/negative influenza testing among their hospitalized infants, were compared using logistic regression analyses. Among 1510 hospitalized infants <6 months old, 151 (10%) had laboratory-confirmed influenza and 294 (19%) mothers reported receiving influenza vaccine during pregnancy. Eighteen (12%) mothers of influenza-positive infants and 276 (20%) mothers of influenza-negative infants were vaccinated (unadjusted odds ratio, 0.53; 95% confidence interval, 0.32-0.88 and adjusted odds ratio, 0.52; 95% confidence interval, 0.30-0.91). Infants of vaccinated mothers were 45-48% less likely to have influenza hospitalizations than infants of unvaccinated mothers. Our results support the current influenza vaccination recommendation for pregnant women.
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