期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 204, 期 6, 页码 -出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2011.02.018
关键词
breastfeeding; leiomyoma; pregnancy; progesterone; ultrasound
资金
- Pfizer
- NICHD [RO1 HD043883, R01 HD049675]
- NIH
- National Institute of Environmental Health Sciences [P30ES10126]
OBJECTIVE: Many fibroids regress with pregnancy or postpartum involution. We sought to identify factors that might inhibit or enhance this natural regression. STUDY DESIGN: We used a prospective cohort of women with fibroids (n = 494) determined by ultrasound screening during the early first trimester identified from the Right from the Start study. Ultrasounds were repeated 3-6 months postpartum (n = 279). Logistic regression analyses were used to identify factors associated with fibroid regression (>50% reduction in volume). RESULTS: Postpartum progestin users had significantly less fibroid regression (P = .01), whereas there was no association for combined estrogen-progestin use. Cesarean delivery and fever (hypothesized to inhibit regression) and breast feeding (hypothesized to enhance regression) were not associated with fibroid regression. CONCLUSION: Progestin use in the postpartum period may limit regression of fibroids, consistent with prior literature on progesterone's role in fibroid development. Research into progestin-only treatments in critical reproductive periods is needed.
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