期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 205, 期 1, 页码 -出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2011.03.039
关键词
folate; cytokine; inflammation; preterm birth
资金
- National Institutes of Health [R01 HD041663, R01 HD052732, K01 MH074092, R01 HD056999]
- National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [UL1 RR024153]
- NIH Roadmap for Medical Research
OBJECTIVE: We previously reported that elevated antiinflammatory cervical cytokines in early pregnancy were associated with spontaneous preterm birth. Our objective was to explore the relation between serum folate vitamers and the lower genital tract inflammatory milieu. STUDY DESIGN: Pregnant women (n = 417) at <16 weeks' gestation had serum samples that were analyzed for folate species 5-methyltetrahydrofolate, 5-formyltetrahydrofolate, and cervical fluid that was assayed for cytokine concentrations. Patterns in proinflammatory cytokines (interleukin [IL]-1 beta, -6, -8, and -10; monocyte chemotactic protein-1) and antiinflammatory cytokines (IL-4, IL-10, IL-13) were identified with factor analysis. RESULTS: After confounder adjustment, maternal serum 5-methyltetrahydrofolate concentrations had a strong negative association with elevated antiinflammatory scores; serum 5-formyltetrahydrofolate concentrations were associated positively with elevated antiinflammatory scores (both P < .05). Maternal folate was not associated with proinflammatory scores. CONCLUSION: Maternal serum folate vitamers are associated with cervical cytokine concentrations, which suggests a possible mechanistic link between folate and preterm birth risk.
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