期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 205, 期 3, 页码 -出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2011.04.002
关键词
asthma; infant viral respiratory infections; vitamin D
资金
- NCRR NIH HHS [KL2 RR024977-04, TL1 RR024978, KL2 RR024977, KL2 RR024977-03, KL2 RR024977-02, UL1 RR024975, KL2 RR024977-05] Funding Source: Medline
- NHLBI NIH HHS [L40 HL086298, L40 HL086298-02A1] Funding Source: Medline
- NIAID NIH HHS [K01 AI070808-04, K24 AI077930-02S1, K24 AI077930, K01 AI070808-03, K01 AI070808-05, K24 AI077930-03S1, K01 AI070808, K01 AI07088, K24 AI077930-03, K24 AI077930-04] Funding Source: Medline
OBJECTIVE: The objective of the study was to investigate the association of maternal vitamin D and maternal asthma and infant respiratory infection severity. STUDY DESIGN: The study included cross-sectional analyses of 340 mother-infant dyads enrolled from September to May 2004-2008 during an infant viral respiratory infection. Maternal vitamin D levels were determined from enrollment blood specimens. At enrollment, we determined self-reported maternal asthma and infant respiratory infection severity using a bronchiolitis score. We assessed the association of maternal vitamin D levels and maternal asthma and infant bronchiolitis score in race-stratified multivariable regression models. RESULTS: The cohort was 70% white, 19% African American, and 21% had asthma. Overall, the median maternal vitamin D level was 20 ng/mL (interquartile range, 14-28). Among white women, a 14 ng/mL increase in vitamin D was associated with a decreased odds of asthma (adjusted odds ratio, 0.54; 95% confidence interval, 0.33-0.86). Maternal vitamin D was not associated with infant bronchiolitis score. CONCLUSION: Higher maternal vitamin D levels were associated with decreased odds of asthma.
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