期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 201, 期 6, 页码 -出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2009.06.024
关键词
isoprostanes; oxidative stress; plasminogen activator inhibitor-1 to plasminogen activator inhibitor-2 ratio; preeclampsia
资金
- General Maternity Hospital Foundation
- Swedish Research Council [8683, 12X-7475]
- Ernfors Family Fund
OBJECTIVE: The aims of this study were to measure the degree of oxidative stress and alterations in plasminogen activator inhibitor (PAI) type 1 and PAI-2 ratio in women with early-onset and late-onset preeclampsia. STUDY DESIGN: A case-control study was conducted in women with early-onset (24-32 weeks' gestation; n = 18) and late-onset (35-42 weeks' gestation; n = 20) preeclampsia and in control pregnant women at corresponding gestational weeks. Placenta, urine, and serum samples were collected. RESULTS: In early-onset preeclampsia, the median placental concentration of 8-iso-prostaglandin (PG)-F(2 alpha) was higher and the PAI-1 to PAI-2 ratio higher than in early controls. These values did not differ between women with late-onset preeclampsia and their corresponding controls. Serum concentrations of 8-iso-PGF(2 alpha) and vitamins C and E did not differ between cases and controls. CONCLUSION: Early-onset but not late-onset preeclampsia is associated with increased placental oxidative stress and increased PAI-1 to PAI-2 ratio.
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