期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 201, 期 1, 页码 -出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2009.02.027
关键词
admixture; genetic ancestry; population stratification
资金
- National Institute of Child Health and Human Development [R01 HD41702, K24 HD 042489]
- National Institute of Environmental Health Sciences [R01ES11682, R21ES11666]
- March of Dimes Birth Defects Foundation [20-FY98-0701, 20-FY02-56, 21-FY07-605]
- Food Allergy Project
OBJECTIVE: In the United States, the rate of preterm delivery (PTD) is higher in African Americans (17.8%) than non-Hispanic whites (11.5%). Such disparity cannot be fully explained by differences in socioenvironmental factors. STUDY DESIGN: We genotyped 812 mothers in a case-control PTD study at Boston Medical Center who self-reported their ethnicity as black. Regression analysis and Wilcoxon rank-sum test were applied to evaluate ancestral distribution and the association between genetic ancestry and PTD-related traits, as well as the potential confounding effect of population stratification. RESULTS: The estimated African ancestral proportion was 0.90 +/- 0.13. We found significant associations of ancestral proportion with PTD as a whole and PTD subgrouped by the presence of maternal hypertensive disorders. We did not observe significant confounding as a result of population stratification in this case-control PTD study. CONCLUSION: Our data underline the need for more intensive investigation of genetic admixture in African Americans to identify novel susceptibility genes of PTD.
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