期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 200, 期 3, 页码 -出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2008.10.019
关键词
breast cancer; coffee consumption; metaanalysis
资金
- National Shanghai Center for New Drug Safety Evaluation
- Shanghai Institute of Pharmaceutical Industry
- Shanghai (Dr Tang)
- Departments of Pharmacology (Drs Zhou and Wang)
- Epidemiology and Biostatistics, School of Public Health ( Dr Yu)
- Nanjing Medical University, Nanjing, Jiangsu Province, China
OBJECTIVE: This metaanalysis was conducted to assess the association between coffee consumption and breast cancer risk. STUDY DESIGN: Relevant studies were identified by searching Medline (1966-May 2008) and the reference lists of retrieved articles. The summary relative risk (RR) with 95% confidence interval (CI) was calculated using a random-effects model. RESULTS: Nine cohort and 9 case-control studies met the inclusion criteria. The combined RR showed a borderline significant influence of highest coffee consumption (RR, 0.95; 95% CI, 0.90-1.00) or an increment of 2 cups/day of coffee consumption (RR, 0.98; 95% CI, 0.96-1.00) on the risk of breast cancer. In stratified analysis, borderline significant associations were observed among cohort and case-control studies and studies conducted in Europe and the United States. However, no significant association was noted among studies conducted in Asia. CONCLUSION: Our findings suggest a possible influence of high coffee consumption or an increased coffee consumption on the risk of breast cancer.
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