期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 199, 期 6, 页码 S340-S344出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2008.09.870
关键词
family history; genetics; preconception
资金
- Intramural NIH HHS [Z99 HG999999] Funding Source: Medline
The prevalence of paternal and maternal genetic conditions that affect pregnancy varies according to many factors that include parental age, medical history, and family history. Although some genetic conditions that affect pregnancy are identified easily early in life, other conditions are not and may require additional diagnostic testing. A complete 3-generation family medical history that includes ethnicity information about both sides of the family is arguably the single best genetic test that is applicable to preconception care. Assessment of genetic risk by an experienced professional has been shown to improve the detection rate of identifiable risk factors. Learning about possible genetic issues in the preconception period is ideal, because knowledge permits patients to make informed reproductive decisions. Options that are available to couples before conception include adoption, surrogacy, use of donor sperm, in vitro fertilization after preimplantation genetic diagnosis, and avoidance of pregnancy. Future technologic advances will increase the choices that are available to couples.
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