期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 198, 期 4, 页码 -出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2007.10.784
关键词
herpes simplex virus 2 infection; perinatal HIV-1; transmission; pregnancy; transmitted infection
资金
- NCRR NIH HHS [RR000188, RR000645] Funding Source: Medline
- NIAID NIH HHS [1 U01 AI 050274-01, N01 AI 085339, U01 AI 034841, U01 AI 034858] Funding Source: Medline
- NICHD NIH HHS [U01 HD 036117, U01 HD 041983, SK12 HD01275] Funding Source: Medline
- NIDA NIH HHS [9U01 DA 015054, U01 DA 015053] Funding Source: Medline
OBJECTIVE: The purpose of this study was to assess the risk of perinatal HIV-1 transmission in women who are coinfected with herpes simplex virus-2 (HSV-2). STUDY DESIGN: We performed a nested case-control study of 26 women whose HIV-1 was transmitted to their infants and 52 control subjects whose HIV-1 was not transmitted. We assessed antepartum serologic evidence of HSV-2 by HSV-2 serostatus and genital tract evidence of HSV-2 by presence of HSV-2 DNA. RESULTS: There was no significant association between antepartum serologic evidence of HSV-2 coinfection and the risk of perinatal HIV-1 transmission. There was also no association between antepartum genital tract evidence of HSV-2 coinfection and risk of perinatal HIV-1 transmission. CONCLUSION: Women who were infected with HIV-1 with antepartum serologic and genital tract evidence of HSV-2 coinfection did not appear to have an increased risk of perinatal HIV-1 transmission. However, further investigations are needed to assess HSV-2 reactivation and the risk of perinatal HIV-1 transmission at the time of delivery.
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