期刊
NATURE REVIEWS IMMUNOLOGY
卷 8, 期 9, 页码 675-684出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2379
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类别
资金
- Institut Pasteur
- Inserm
- Marie Curie Excellence
Interactions between T cells and dendritic cells (DCs) in the lymph nodes are crucial for initiating cell-mediated adaptive immune responses. With the help of two-photon imaging, the complexity of these cellular contacts in vivo has recently been captured in time-lapse movies in several immunological contexts. Well beyond the satisfaction of seeing a T-cell response as it happens, these experiments provide fundamental insights into the regulation and the biological meaning of T-cell-DC contact dynamics. This Review focuses on how this emerging field is changing our perception of T-cell activation by DCs.
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