期刊
AMERICAN JOURNAL OF NEPHROLOGY
卷 29, 期 1, 页码 62-70出版社
KARGER
DOI: 10.1159/000151277
关键词
Angiotensin II; Dyslipidemia; Mesangial matrix; NADPH oxidase; Reactive aldehydes; TGF-beta signaling
Glomerulosclerosis frequently complicates most renal diseases and is characterized by mesangial matrix accumulation. Oxidized low-density lipoprotein (Ox-LDL) could induce oxidative stress and profibrotic gene expression in mesangial cells. This article will review our current understanding of the pathogenetic mechanisms of lipid-mediated glomerulosclerosis, emphasizing the fibrogenic signaling cascades triggered by Ox-LDL. In addition, therapeutic strategies to prevent the development of Ox-LDL-mediated glomerulosclerosis will be discussed. Copyright (C) 2008 S. Karger AG, Basel
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