期刊
HEAD & NECK PATHOLOGY
卷 2, 期 3, 页码 169-174出版社
SPRINGER
DOI: 10.1007/s12105-008-0068-z
关键词
Kallikreins; Human kallikrein 8; Salivary gland tumors; Prognostic markers; Immunohistochemistry
类别
资金
- National Organization for Rare Disorders
The human kallikrein 8 protein (KLK8) is expressed in many normal tissues including esophagus, skin, testis, tonsil, kidney, breast, and salivary gland, and is found in biological fluids including breast milk, amniotic fluid, seminal fluid and serum. It has also been shown to be a biomarker and prognostic factor for breast cancer. The aim of this study was to determine whether KLK8 is expressed in salivary gland tissues and salivary gland tumors (both benign and malignant), in order to compare normal with tumor tissues. Pleomorphic adenomas, adenoid cystic carcinomas, polymorphous low grade adenocarcinomas, acinic cell carcinomas, mucoepidermoid carcinomas, and adenocarcinomas NOS of both minor and major salivary glands were examined. The results of this study indicate that most salivary gland tumors show high levels of expression of KLK8.
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