期刊
EMERGING INFECTIOUS DISEASES
卷 14, 期 9, 页码 1398-1405出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid1409.080570
关键词
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资金
- German Ministry of Health
- German Ministry of Education and Research [01 KI 0203]
- European Union [SSPE-CT-2005-022639]
- Foundation for Research Support of the State of Bahia [APR 125/2006]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil
Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple sclerosis-like disseminated encephalomyelitis. Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was sequenced and classified as a cardiovirus. We conducted systematic molecular screening for Saffold-like viruses in 844 fecal samples from patients with gastroenteritis from Germany and Brazil, across all age groups. Six cardioviruses were identified in patients < 6 years of age. Viral loads were 283,305-5,044,412,175 copies/g of stool. Co-infections occurred in 4 of 6 children. No evidence for outbreak-like epidemic patterns was found. Phylogenetic analysis identified 3 distinct genetic lineages. Viral protein 1 amino acids were 67.9%-77.7% identical and had a distance of at least 39.4% from known cardioviruses. Because closely related strains were found on 2 continents, global distribution in humans is suspected. Saffold-like viruses may be the first human cardiovirus species to be identified.
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