期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
卷 160C, 期 2, 页码 118-129出版社
WILEY
DOI: 10.1002/ajmg.c.31327
关键词
copy number variants; variable penetrance; genomic disorders; autism; schizophrenia; intellectual disability
资金
- Canadian Institutes of Health Research
- American Society of Human Genetics
Despite detailed clinical definition and refinement of neurodevelopmental disorders and neuropsychiatric conditions, the underlying genetic etiology has proved elusive. Recent genetic studies have revealed some common themes: considerable locus heterogeneity, variable expressivity for the same mutation, and a role for multiple disruptive events in the same individual affecting genes in common pathways. Recurrent copy number variation (CNV), in particular, has emphasized the importance of either de novo or essentially private mutations creating imbalances for multiple genes. CNVs have foreshadowed a model where the distinction between milder neuropsychiatric conditions from those of severe developmental impairment may be a consequence of increased mutational burden affecting more genes. (c) 2012 Wiley Periodicals, Inc.
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