Variation at the GABAA Receptor Gene, Rho 1 (GABRR1) Associated With Susceptibility to Bipolar Schizoaffective Disorder

We have previously reported evidence that variation at GABA(A) receptor genes is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene-wide significance at GABRB1, GABRA4, GABRB3, GABRA5, and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P 0.052). (c) 2010 Wiley-Liss, Inc.