期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
卷 150B, 期 5, 页码 653-659出版社
WILEY
DOI: 10.1002/ajmg.b.30885
关键词
inflammatory cytokine; IL-1 beta; depression; childhood; genetics
资金
- National Institute of Mental Health [NIH-56193]
- National Alliance for Research on Schizophrenia and Depression
- Canadian Institutes of Health Research [MOP-71935]
- Ontario Mental Health Foundation
Given substantial evidence for IL-1 beta involvement in the etiology of depression, the IL1B gene is a strong candidate for involvement in susceptibility to depressive disorders. However, association studies investigating this, to date, have been limited to just two polymorphisms (rs1143627[-31T/C] and rs16944[-511C/T]) that constitute only a fraction of the genetic variation that is actually present across this gene in the population. Here, in a family-based association study of childhood-onset mood disorders (COMD), characterized by onset of depression before the age of 15, we have used a gene-wide approach, employing a panel of five tagging SNPs spanning the entire gene. Based on TDT analyses of both individual alleles and haplotypes, in a study sample of 646 families (with 782 affected children), none of the SNPs, including those implicated in transcriptional regulation of the gene, showed evidence for association with COMD. This is the largest and most comprehensive study of IL1B in relation to mood disorders that has been carried out, to date. The results do not support the involvement of IL1B as a major factor in genetic risk for early-onset mood disorders. (C) 2008 Wiley-Liss, Inc.
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