期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
卷 150B, 期 2, 页码 300-306出版社
WILEY
DOI: 10.1002/ajmg.b.30798
关键词
association; autism spectrum disorders (ASD); candidate gene study; nitric oxide synthase type I (NOS-I); nitric oxide synthase type II (NOS-IIA)
资金
- Korea Research Foundation Grant
- Korean Government (MOEHRD, Basic Research Promotion Fund) [KRF-2006-311-E00266, R14-2003-002-01001-0]
- Gachon University of Medicine and Science
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a strong genetic component and environmental risk factors. Nitric oxide (NO), which is produced by nitric oxide synthase (NOS), may play a role in the development of ASD. We genotyped nine single nucleotide polymorphisms (SNPs) in the NOS-I gene and nine SNPs in the NOS-IIA gene and carried out the transmission disequilibrium test (TDT) and haplotype analysis in 151 Korean ASD trios. We found preferential transmission of the A allele of rs8068149 (P = 0.039) and G allele of rs1060826 (P = 0.035) of NOS-IIA in ASD and the haplotype analysis revealed that the two haplotypes had significant associations (P = 0.014 and 0.031, respectively). The behavioral subdomain score of failure to use nonverbal behaviors to regulate social interaction in Autism Diagnostic Interview-Revised (ADI-R) was significantly higher in subjects with the GG or AG allele in rs1060826 of NOS-IIA compared to those who had the AA allele (P = 0.027). These results provide significant but weak evidence for an association between NOS-IIA and ASD in the Korean population. (C) 2008 Wiley-Liss, Inc.
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