期刊
NATURE REVIEWS IMMUNOLOGY
卷 8, 期 9, 页码 685-698出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2378
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资金
- Crohn's & Colitis Foundation of America
- Cancer Research Institute
- Howard M. Goodman
- Center for the Study of IBD [DK 43351]
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology
- Naito Foundation
- Uehara Memorial Foundation
- National Institutes of Health [AI061663, AI069259, AI072252, HL56949, AR42689]
Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. We present and discuss our current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-specific lymphocyte homing, the production of specific antibody isotypes and regulation of the immune response. Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity.
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