期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
卷 158A, 期 11, 页码 2925-2930出版社
WILEY-BLACKWELL
DOI: 10.1002/ajmg.a.35610
关键词
12q14 microdeletion; HMGA2; LEMD3; osteopoikilosis; short stature
资金
- Ministry of Higher Education of Saudi Arabia (FSA)
- Research Institute at Nationwide Children's Hospital
The 12q14 microdeletion syndrome is a rare condition that has previously been characterized by pre- and postnatal growth restriction, proportionate short stature, failure to thrive, developmental delay, and osteopoikilosis. Previously reported microdeletions within this region have ranged in size from 1.83 to 10.12?Mb with a proposed 2.61?Mb smallest region of overlap containing the LEMD3, HMGA2, and GRIP1 genes. Here, we report on the identification of a 12q14 microdeletion in a female child presenting with proportionate short stature, failure to thrive, and speech delay. The genomic loss (minimum size 4.17?Mb, maximum size 4.21?Mb) contained 25 RefSeq genes including IRAK3, GRIP1, and the 3' portion of the HMGA2 gene. This is the first partial deletion of HMGA2 associated with the 12q14 microdeletion syndrome. This case further clarifies the association of LEMD3 deletions with the 12q14 microdeletion syndrome and provides additional support for the role of the HMGA2 gene in human growth. (c) 2012 Wiley Periodicals, Inc.
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