Characterization of fat distribution in Prader-Willi syndrome: Relationships with adipocytokines and influence of growth hormone treatment

Marked anthropometric changes are seen in PraderWilli syndrome (PWS). Emaciation is observed during infancy, whereas severe obesity is found in older children and adults. Growth hormone (GH) treatment modifies the anthropometric changes in PWS patients. In this study, we examined changes in the body composition of 51 PWS patients (age range, 654 years; median, 16.5 years), with a focus on the amount of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), VAT/SAT ratio, and serum levels of adipocytokines (adiponectin, leptin, and resistin). The relationships between VAT, SAT, and adipocytokines, and lipid abnormalities and type 2 diabetes in 24 patients with obese PWS were also evaluated. With increasing age, SAT and VAT both increased markedly, but in 18 patients receiving GH treatment, VAT remained low at =30?cm2. In the GH-completed patients (n?=?19), VAT and SAT increased with age to levels similar to those in non-GH-treated patients (n?=?14). In the obese group, adiponectin decreased as VAT increased (r?=?0.35, P?=?0.11). Leptin (r?=?0.67, P?