期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
卷 155A, 期 2, 页码 270-279出版社
WILEY
DOI: 10.1002/ajmg.a.33702
关键词
neural crest cells; craniofacial development; neurocristopathies
资金
- Eunice Kennedy Shriver National Institute of Child Health & Human Development [K12HD001255]
- Eleanor and Miles Shore Scholars in Medicine
- Harvard Medical School
- National Institute of Health (NIH) [K99DE019853-01]
The craniofacial region is assembled through the active migration of cells and the rearrangement and sculpting of facial prominences and pharyngeal arches, which consequently make it particularly susceptible to a large number of birth defects. Genetic, molecular, and cellular processes must be temporally and spatially regulated to culminate in the three-dimension structures of the face. The starting constituent for the majority of skeletal and connective tissues in the face is a pluripotent population of cells, the cranial neural crest cells (NCCs). In this review we discuss the newest scientific findings in the development of the craniofacial complex as related to NCCs. Furthermore, we present recent findings on NCC diseases called neurocristopathies and, in doing so, provide clinicians with new tools for understanding a growing number of craniofacial genetic disorders. (C) 2010 Wiley-Liss, Inc.
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