期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
卷 146A, 期 12, 页码 1624-1633出版社
WILEY
DOI: 10.1002/ajmg.a.32301
关键词
neurofibromatosis type 1; NF1; pregnancy; steroid hormones; steroid hormone receptors
资金
- NINDS NIH HHS [R01 NS17262] Funding Source: Medline
The Neurofibromatosis Type 1 (NF1) gene functions as a tumor suppressor gene. Loss of its protein, neurofibromin, in the autosomal dominant disorder NF1 is associated with peripheral nervous system tumors, particularly neurofibromas, benign lesions in which the major cell type is the Schwann Cell (SC). Benign and malignant human tumors found in NF1 patients are heterogeneous with respect to their cellular composition. The number and size of neurofibromas in NF1 patients has been shown to increase during pregnancy, with, in some cases, post-partum regression, which suggests hormonal involvement in this increase. However, in this review, we consider evidence from the literature that both direct hormonal influence on tumor growth and on angiogenesis may contribute to these effects. (C) 2008 Wiley-Liss, Inc.
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