期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 76, 期 4, 页码 258-271出版社
WILEY
DOI: 10.1111/aji.12454
关键词
Antioxidants; immunoregulation; intrauterine growth restriction; preeclampsia; spontaneous abortion
资金
- National Basic Research Program of China [2013CB967404, 2011CB944400]
- National Natural Science Foundation of China [81125004, 81401218]
- Fund for Outstanding Academic Leaders in Shanghai, China [2013-049]
- Shanghai Jiao Tong University Medicine-Engineering Fund [YG2013ZD04]
During pregnancy, the placenta is a site of active oxygen metabolism that continuously generates oxidative stress (OS). Overproduction of reactive oxygen species and reactive nitrogen species can destroy normal placental functions. Therefore, the feto-placental unit generates abundant antioxidants to keep OS under control. Properly controlled oxidative species have been proven to serve as indispensable cellular signal messengers by regulating gene expression and downstream cellular activities. OS also plays an important immunoregulatory role during pregnancy. Oxidative disorder and immune disturbances are associated with adverse pregnancy outcomes such as spontaneous abortion, preeclampsia and intrauterine growth restriction. In this review, we introduce recent studies revealing basal functions and regulatory roles of placental OS in metabolism and immunity. The relationships between OS-and pregnancy-related disorders are also discussed.
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