期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 75, 期 4, 页码 426-439出版社
WILEY
DOI: 10.1111/aji.12431
关键词
Animals; contraceptive vaccines; GnRH vaccine; PZP vaccine; surgical sterilization
An alternative to surgical sterilization for fertility control of animals (wild, zoo, farm, and domestic) is needed to prevent problems related to overpopulation, including culling and relocation. A PubMed and Google Scholar database search was conducted using the keywords contraceptive vaccine animals,' immunocontraception animals,' non-surgical sterilization animals,' PZP vaccine,' and GnRH vaccine.' The searches from 1972 to 2015 yielded over 1500 publications. These articles were read, and 375 were selected for detailed analysis. Articles referenced in these publications were also thoroughly examined. PZP and GnRH contraceptive vaccines (CVs) have been extensively investigated for fertility control of wild, zoo, farm, and domestic animal populations. Both vaccines have shown tremendous success with PZP vaccines taking the lead. Novel technologies and targets are being developed to improve existing vaccines and generate second-generation CVs. Single-shot vaccines, which can be delivered remotely, will greatly advance the field of immunocontraception for animal use with potential human application.
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